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82 The promising mechanism of action of TLK286 and its positive preclinical data have sparked a series of clinical trials where the prodrugs have been applied alone or in combination with other standard chemotherapeutic agents
Results are displayed in milligrams per millilitre (mg/mL) and micrograms per millilitre (g/mL)
Moreover, treatment with mitochondria-targeted antioxidant MitoQ preserves mitochondrial quality control, alleviates tubular injury, and restores kidney function by reversing mitophagy deficiency through the Nrf2/PTEN-induced kinase 1 (PINK) signaling pathway in db/db mice (68)
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Xu S, et al
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