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Measurement of islet size area Dissected pancreata were fixed in Formalin (Formalin 10% neutral buffered, HT501128, Sigma-Aldrich) for 24 h at room temperature and standardly processed for paraffin embedding (Tissue Tec VIP.6, Sakura Europe) Paraffinized pancreata were exhaustively cross-sectioned into four parallel, equidistant slices per case

This suggests that the drastic inhibition of GLP-1 secretion by shutdown of the main pathway via the SSTRs-Gi axis is the primary cause of pasireotide-induced hyperglycemia

This protection is vital for preventing chronic diseases and promoting overall health

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Bei der Biotransformation werden Fremdstoffe ohne physiologische Funktion gebunden, wasserlslich gemacht (Toxine sind meist fettlslich) und ber den Harn oder Stuhl ausgeschieden