semaglutide in chronic kidney disease Long-term outcomes of obesity and cardiovascular in the SELECT trial can semaglutide cause kidney problems

This may be due to its role in downregulating naive genes (Fig

Only 1.6% of participants discontinued due to nausea, meaning the vast majority found it manageable over time (Wilding et al., NEJM 2021)

Important Observations Body Composition Changes: Increases in lean mass during the weight maintenance phase were partly attributed to the restoration of water content post-rapid weight loss, adding nuance to the observed physiological effects

These factors help a clinician understand medical need, risk level, and likely benefit

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