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Examining the adaptive processes that are established to respond to the initial CS burden may help to understand what pathways become defective or are compromised and may contribute to the pathogenesis of COPD
PMID 27178543
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She was on a DMARD and a biologic both at full doses and still having multiple flares per month
According to the Summary of Product Characteristics (SmPC), the most commonly reported adverse effects include: Nausea and vomiting (very common) particularly during dose escalation Diarrhoea or constipation (very common) affecting bowel regularity Abdominal pain and discomfort (common) often mild to moderate Reduced appetite (very common) contributing to weight loss Dyspepsia (common) indigestion or heartburn Injection site reactions (common) such as redness or irritation Fatigue (common) tiredness or lack of energy These gastrointestinal symptoms typically diminish over time as the body adjusts to the medication
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