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When collagen naturally breaks down in the skin, the resulting peptide fragments signal to the skin that it should get to work and create some nice, new collagen
Effect of Dietary Carnitine Isomers and -Butyrobetaine on L-Carnitine Biosynthesis and Metabolism in the Rat
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The post says freezing damages the active compound and renders the medication ineffective, and that consistent moderate cold is what preserves the peptide structure driving its mechanism of action
and Paszat, L.F., 2010
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