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However, these findings are difficult to generalize, as graft integration depends strongly on the lesion environment, and near-normal connectivity can still be achieved in the adult brain under certain conditions, such as in the context of synapse loss (Falkner et al., 2016

The largest contributor to cytosolic NADPH is the oxidative PPP in mammalian cells

However, there are also cases when additional factors such as lack of sleep, poor diet, and deficiency of other vitamins like iron, folate, and others, contribute to the issue