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Overall, the affinitypotency profile of tirzepatide was 360-fold weaker relative to mGIP at the mGIPR, with similar or slightly reduced potency compared to GLP-1 at the mGLP-1R (Extended Data Table 1)
But like all great tools, you also need to understand the side effects and one of the things were seeing more frequently is how they can affect the gallbladder when patients lose weight rapidly. What are GLP-1 Medications and how do they Affect the Gallbladder
doi: 10.2337/db20-89-LB 78 StensenSGasbjergLSKroghLLSkov-JeppesenKSparre-UlrichAHJensenMHet al
Furthermore, since Mounjaro mimics GLP-1 hormone effects, it may influence bodily fluid balance and potentially impact tear production and evaporation
Yes, many patients successfully switch between GLP-1 agonists and GIP/GLP-1 agonists when tolerability improves the fit
In this case, rapid weight loss is the main cause
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