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The lumps should gradually soften and shrink

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Providers should discuss expected timelines, realistic efficacy ranges, and when to reassess treatment if outcomes differ from predictions

No, tirzepatide should not be frozen , as freezing can damage the formulation and alter its molecular structure, making it unsafe or ineffective to use

For significant weight loss, semaglutide or another GLP-1 medication is the more impactful foundation

There is no clinical evidence that injection timing affects efficacy