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Peptide 20 was developed through a series of optimizing processes based on GCGR agonism in diet-induced obese mice, concluding that the ideal metabolic benefits of triagonism predominantly depend on fine-tuning the GCG component 14

Further, the trial included an open-label liraglutide arm as reference (liraglutide with a 2-week dose escalation uptitrated to 1.8 mg once daily), which resulted in similar body weight reductions compared with the dual GIP/GLP-1 receptor agonist (although not directly comparable) [23]

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Zhou, X., Liu, F., and Zhai, S

Standard semaglutide titration schedule explained week by week The titration schedule exists for one reason

Also reduces fat accumulation in the liver