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Graphical Abstract Highlights To determine whether there is a potential relationship between glucagon-like peptide 1 receptor agonists (GLP-1RAs) and suicidal or self-injurious behaviors (SSIBs)

Strategies to Minimize Side Effects: Start with a low dose and increase gradually Eat smaller, more frequent meals Avoid high-fat and high-sugar foods Stay well-hydrated Take anti-nausea medication if recommended by your provider Get adequate sleep and manage stress Your medical team will monitor you closely and provide personalized strategies to manage any side effects

For hospitalization for heart failure analysis, person-trials with a history of outcome events were excluded (unweighted N = 5,834,041)

282 The resulting amplification loop, involving neutrophil- and macrophage-derived TNF-, intensifies the local inflammatory response in the pancreas

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