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The involvement of GLP-1 in PD can be simplified to the activation of the MAPK/extracellular signal-regulated kinase 1/2 (ERK) pathway, which has an important role in synaptic plasticity, and the PI3K/Akt pathway signaled by GLP-1 receptor stimulation and the subsequent increase in cAMP and PKA and PI3K activation [73]
doi: 10.3390/nu13041136 181
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Before initiating treatment with GLP-1 receptor agonists, healthcare professionals should consider obtaining baseline liver function tests (LFTs) , including ALT, AST, alkaline phosphatase (ALP), and bilirubin, particularly in patients with risk factors for liver disease
Lancet Psychiatry
