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doi: 10.18632/aging.101759 223 OkaJSuzukiEKondoY
Foundational work from the de Keizer laboratory (Baar et al., Cell, 2017) reported that the peptide perturbs the FOXO4-p53 association, leading to p53 nuclear exclusion and apoptosis that appeared preferential to senescent cells in cultured cells and aged mouse models
It promotes cell migration, angiogenesis (new blood vessel formation), and helps reduce inflammation
Weight changes are usually water/glycogen
After 20 g/L glucose was depleted in YP20D medium, a feeding solution containing 200 g/L yeast extract, 100 g/L peptone, and 600 g/L glucose was supplied at 2.415.8 mL/h
