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Compelling evidence from landmark clinical trials, particularly STEP-HFpEF, STEP-HFpEF DM and SUMMIT, has established the efficacy of GLP-1RAs in improving HF-related symptoms and quality of life, as well as reducing worsening HF events, in the prevalent phenotype of HFpEF in the setting of obesity and T2D

The dominant real-world format: a small molecule, not a peptide, so swallowing it is legitimate

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It can also form a thin protective film on skin

When used appropriately by the right patients and under the proper supervision, GLP-1 medications can help teens with severe obesity reclaim their health, energy, and confidence