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415 Antidepressants target astrocytes Antidepressant drugs include (i) selective serotonin reuptake inhibitors (SSRI), of which fluoxetine (Prozac) is the most popular, (ii) serotonin/noradrenaline reuptake inhibitors (SNRI), (iii) tricyclic antidepressants, (iv) inhibitors of monoaminoxidase, (v) lithium, and (vi) ketamine
GPX4 utilizes GSH to reduce lipid peroxides of PUFAs to lipids, maintaining the balance between lipid peroxides and lipids
By tissue type, the application that has the strongest evidence base is soft tissue: muscle strains, ligament sprains, and chronic tendinopathies
Studies have shown significant declines in VAT, hepatic fat, and trunk-to-appendicular fat ratio with tesamorelin treatment
Inhibiting SCD expression by IGF1R during lorlatinib therapy sensitizes melanoma to ferroptosis
Some studies suggest that prolonged or excessive mTOR inhibition may impair muscle protein synthesis and potentially exacerbate sarcopenia in older adults, highlighting a possible trade-off between metabolic benefits and preservation of lean massan area requiring further investigation [28]
