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The licensing of oral semaglutide provided a step forward in type 2 diabetes management for this group, and the publication of the SOUL study in 2025 reassured us that oral semaglutide could also offer cardiovascular benefit in those at highest risk
Semaglutide has been shown to be effective for weight loss in people with obesity
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Future studies are needed to determine if GLP-1R pharmacotherapy has similar effects on VTA GABA neurons during cue-induced and/or stress-induced reinstatement
Related Stories Generic semaglutide could improve diabetes treatment affordability in Canada Semaglutide and tirzepatide linked to fewer alcohol-related hospital visits GLP-1 receptor agonists may increase hair loss risk Considering the SELECT trial report, the experts indicated the beneficial effects of continuing semaglutide treatment, particularly in patients with cardiovascular disease, even if they do not undergo the recommended weight loss
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