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Because both substances affect blood sugar and digestion, taking them at the same time can lead to additive effects. This means the two substances might stack their impact, making the effects much stronger than if you took either one alone

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(C) -hydroxybutyrate was quantified in the supernatant of aILC2s incubated for 24h with and without melatonin

Neeland IJ, Gupta S, Ayers CR, Turer AT, Rame JE, Das SR et al (2013) Relation of regional fat distribution to left ventricular structure and function