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A 2019 meta-analysis in European Journal of Endocrinology found that each 10% reduction in body weight was associated with a 2-3 nmol/L increase in total testosterone, placing the weight loss achieved with tirzepatide well within the range needed for clinically meaningful hormonal improvement (Corona et al., 2019, European Journal of Endocrinology )

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GLP-1 and related medications are usually considered for patients with obesity or overweight plus weight-related medical conditions