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Este trabajo revisa las opciones farmacolgicas para tratar la obesidad, profundizando en los beneficios asociados al uso novedoso de agonistas del receptor de GLP-1 (arGLP-1), que actan sobre los centros de la saciedad

Clinical trials show tirzepatide producing 2022% average weight loss versus approximately 15% for semaglutide

Strategy of targeting ligand functionalization significantly relies on the receptor expression, and stimuli-triggered BBB disruption has limited resolution

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Nrf2 upregulates the expression of dozens of cytoprotective enzymes, including GCL itself, creating a compensatory response to oxidative stress

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