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Restoring a deficiency can help you feel like yourself again, but if your levels are already normal, adding more B12 will not create extra energy or other effects your body cannot use

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The pivotal Phase 2 trial (NCT04881760), published in The New England Journal of Medicine (Jastreboff et al., 2023), enrolled 338 adults with BMI 30 or higher

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In practice, this involves giving an initial 4 g IV infusion of pyridoxine, followed by repeated 1 g IM injections every 30 minutes until the total matched dose is reached

Typical schedules range from weekly to every other week, depending on your providers protocol and your response