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At The Center for Occupational and Environmental Medicine (COEM), intravenous administration is considered when laboratory findings, exposure history, or clinical presentation suggest increased oxidative burden or impaired detox capacity

doi: 10.1016/S0039-6028(02)01375-4 27 NawazT.ShafiM.KhaliqA

Transcriptional regulator of oxidative stress-inducible genes: direct activation by oxidation

Much of the human data is therefore older, and the compound never accumulated the kind of modern, well-controlled trials that would settle the question

KPV interferes with this translocation, keeping NF-kB in the cytoplasm where it remains inactive