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From the comparative analysis of the results of comparative example 1 and examples 19, 20, 21 and 22, the synthesis of semaglutide was performed after introducing an ionic liquid Linker on the PS resin solid phase support, and the crude peptide purity and the refined peptide yield were much better than those of the standard Fmoc solid phase polypeptide synthesis method
Akt is activated as a result of insulin or insulin growth factor signaling and plays a vital role in GLUT4 translocation 20
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Adv Ther 2022;39:2452-67
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