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SNX-0723, identified through scaffold-based screening, selectively binds the ATP-binding pocket of HSP90 and demonstrates improved brain penetration, reducing mutant huntingtin aggregation in PD and HD models
La rduction de l'indice de mlanine tait statistiquement significative par rapport au placebo dans la majorit des essais, mais les auteurs ont conclu que les limites mthodologiques principalement la petite taille des cohortes et l'absence de donnes long terme ne permettaient pas de considrer l'effet claircissant comme bien tabli
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Temperature excursions above 25C for more than 24 hours degrade methylcobalamin and can oxidise methionine
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