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It helps to define the two compounds up front
Next Order Effects of Increasing GLP-1 Use
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doi:10.1056/NEJMoa2301972 PubMed: This landmark study demonstrated 24.2% mean weight loss at 48 weeks with the 12mg dose in 338 adults with obesity, establishing retatrutide as the most effective obesity medication tested to date
However, no robust clinical trials yet confirm this specific combination improves outcomes beyond either agent alone
Those taking GLP-1s were affected the most: they had the most pronounced regain
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