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D4F prophylaxis enables redox and energy homeostasis while preventing inflammation during hypoxia exposure

Lancet 352 , 15861589 (1998)

Nitric oxide is a critical signaling molecule involved in vasodilation, blood flow regulation, immune function, and tissue repair

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This route of administration can be particularly beneficial for patients who have difficulty swallowing oral medications or for those where oral administration is not optimal due to gastrointestinal issues

6 While it is recommended that patients be tested for G6PD deficiency prior to starting rasburicase, this is not always possible due to the high risk of morbidity and mortality associated with TLS