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GLP-1 receptor agonists and cardiovascular disease in patients with type 2 diabetes

According to StatPearls (NCBI), semaglutide provides glucose-lowering effects in a glucose-dependent manner, which means it primarily stimulates insulin when blood sugar is elevated reducing the risk of low blood sugar (hypoglycemia) compared to some other medications

Many people also report a lower appetite and early satiety (getting full before finishing a meal), one reason Ozempic is sometimes prescribed off-label for weight loss

In OASIS-4, gastrointestinal side effects were reported in about 74% of participants taking oral semaglutide, compared with 42% in the placebo group

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GLP-1 receptors are distributed throughout multiple organ systems, including the pancreas, gastrointestinal tract, cardiovascular system, and importantly, the central nervous system