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The follow-on open-label extension published by Steven Grinspoon and colleagues in 2010 and 2012 confirmed that the VAT reduction was maintained through 52 weeks of continuous dosing and that patients who switched from placebo to active compound at week 26 caught up to the original treatment arm by week 52

A reasonable bar would be at least one published phase 2 trial showing clinical efficacy with acceptable safety in humans

Neuropathology of vitamin B(12) deficiency in the Cd320(-/-) mouse

1 , CD000400 (2013)

41 Recent research has reported decreased levels of GSH and increased levels of free radicals in brain tissue samples of HIV individuals, reducing neuroprotection and increasing the risk and occurrence of TB meningitis

The role of obesity on inflammation and damage in spondyloarthritis: a systematic literature review on body mass index and imaging