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In a 12-month clinical trial involving 404 HIV-infected patients with excess abdominal fat, Tesamorelin (2 mg daily) significantly reduced visceral adipose tissue (VAT) compared to placebo

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Experimental investigations have reported interactions with VEGFR2 phosphorylation, focal adhesion kinase (FAK) activation, ERK1/2 signaling, nitric oxide-associated pathways, and extracellular matrix regulatory networks

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