I dont think that is clear from the research and there are a lot of different components of appetite regulation, fat storage, and base metabolic rate that come into play with obesity
Selenium is an essential micronutrient very important for various aspects of human health (239)
The Intestinal Barrier Your gut lining is made up of enterocytes (nutrient-absorbing cells) and supported by mucus-producing goblet cells, immune-releasing enterochromaffin cells, antimicrobial Paneth cells, and M cells that survey for invaders
Neuropsychopharmacology 2008, 33(9):21872199
Hence the need for loading doses
It may influence cellular methylation balance, metabolic signaling, and NAD-related biochemical pathways