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The adrenal medullary chromaffin cells are functionally equivalent to postganglionic neurons of the sympathetic nervous system and in response to acetylcholine release from sympathetic preganglionic neurons these cells release epinephrine and norepinephrine into the circulation
Tirzepatide patients lost an average of 20.2% of their body weight, while semaglutide patients lost 13.7%, a difference of 6.5 percentage points.[1] In practical terms, for someone starting at 250 pounds, that means losing roughly 50 pounds (22.8 kg) on tirzepatide versus 33 pounds (15.0 kg) on semaglutide.[1] Waist circumference shrank by an average of 7.2 inches (18.4 cm) with tirzepatide versus 5.1 inches (13.0 cm) with semaglutide, a difference with real implications for heart disease risk.[1] When researchers looked at more dramatic weight loss thresholds, tirzepatide pulled further ahead
Zhang R, et al
Additionally, genetic predisposition to severe autoimmune T2DM is associated with an increased risk of focal epilepsy (83)
