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Malaguarnera, M., Vacante, M., Bertino, G., Neri, S., Malaguarnera, M., Gargante, M

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Notably, the C-terminal FAP cleavage site remains unmodified, suggesting that LY2405319 is likely susceptible to cleavage and inactivation in human serum via loss affinity for KLB ( Figure 3A )

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Figure 3 Another analog, PF-05231023, is a 190 kDa molecule consisting of human FGF21 covalently linked to each Fab region of a humanized IgG1 mAb scaffold, resulting in a 2:1 stoichiometry of FGF21 molecules per scaffold (292)

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