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To further explore whether metformin exerted its protective effects through the Nrf2 signaling pathway, Nrf2 expression was knocked-down in the chondrocytes by Nrf2 siRNA transfection, and then the Nrf2-knocked-down chondrocytes were treated with H 2 O 2 and metformin
It is interesting to note that when combined with conventional chemotherapy drugs such as doxorubicin, cyclophosphamide, and taxanes, these fatty acids improve cancer cells sensitivity to cytotoxic drugs, lessen side effects like cachexia, neuropathy, or myelosuppression, or overcome multidrug resistance (168)
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Dosing for musculoskeletal applications: Typical protocols use 200-500mcg BPC-157 daily via subcutaneous or intramuscular injection
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