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10.1093/brain/awl356 48 KuoM
Changes are quite likely more related to increased systemic inflammation, BBB disruption, and cognitive outcome deterioration (Silva et al., 2020)
Mater Chem
Chronic Complication Mechanisms: Sustained hyperglycemia damages small vessels (microvascular disease) via multiple mechanisms including AGE accumulation, protein kinase C activation, and hexosamine pathway flux
Altogether, these data will have to be firmly established by complementary experiments, especially if a cleavage could also generate soluble isoforms
The key is intention and moderation
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