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In this context, the present review covers the genetic and endocrine mechanisms of obesity and the current therapeutic strategies for managing obesity in PWS

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However, the H3R also functions as a heteroreceptor and has been shown to be expressed in several brain regions other than the TMN (58, 60, 116)

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The combination yields greater weight loss than either agent alone, with mean reductions in body weight of approximately 20.4% over 68 weeks in non-diabetic adults and 13.7% in those with type 2 diabetesfar exceeding placebo and monotherapy arms