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however, corticosterone deficiency does not mediate the favorable metabolic phenotype of Gipr(/) mice

doi: 10.1002/JLB.MR0618-213R 245 SchieberM.ChandelN

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Beyond a certain threshold, higher doses don't produce additional benefits and may actually reduce effectiveness through receptor desensitization

Sensitivity analyses were performed to assess the impact of the definition of MACE (three-point MACE [non-fatal myocardial infarction, non-fatal stroke and cardiovascular death] vs other MACE definitions), risk of bias, data source (electronic healthcare records vs other data sources) and method of adjusting for confounding (propensity scores or inverse probability of treatment weighting vs multivariable regression, restriction or matching)