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Some patients find B12 to be very stimulating, if you fall into this category its best to use it early in the day as opposed to in the evening

Untreated vitamin B12 deficiency can lead to anemia or irreversible nerve damage

A good starting dose would be 500mcg (0.5mg) per day, but you can give up to twice as much

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That being said, neither study specifically states how much one must take of vitamin B12 (or folate) for their blood serum levels to register as either "very high" or "extremely high." For that reason, although vitamin B12 (and folate) supplementation are important during pregnancy, it's best to look to your healthcare provider for guidance