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Phase 3 Update: TRIUMPH-4 Results Preliminary data from the ongoing Phase 3 TRIUMPH-4 trial (68 weeks) shows higher numbers than Phase 2: 12mg dose: 28.7% average weight loss (~71 lbs / 32 kg) 9mg dose: 26.4% average weight loss (~64 lbs / 29 kg) Knee osteoarthritis pain: 76% reduction (significant quality-of-life improvement) Blood pressure: Average reduction of 14 mmHg Full Phase 3 results across the TRIUMPH program (obesity, diabetes, cardiovascular outcomes, kidney outcomes) are expected throughout 2026

By helping to stabilize blood sugar levels, Semaglutide can decrease the risk of diabetes-related complications, enhancing overall health and quality of life

Stress management and cortisol control Chronic stress elevates cortisol, which promotes abdominal fat storage, increases insulin resistance, and drives cravings for high-calorie comfort foods

Taken together, these preclinical data support interventions that target UA to counteract oxidative stress in the ischemic penumbra and protect endothelial cell function after cerebral ischemia-reperfusion injury

It is part of a class of medications called GLP-1 receptor agonists, which work with natural hormones in the body

PMID 23319032