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However, parasites quickly develop resistance against these antimalarials

It is a nonspecific and uncontrolled process in which the resulting reactive oxygen species readily react with surrounding molecules, leading to intensification of the process, and the damage of the cell membrane

Early characterization described it as a sleep-modulator, one that appeared to shift sleep architecture toward deeper stages rather than simply inducing unconsciousness

They are generally used in cycles with scheduled breaks, often several weeks on followed by time off, to reduce the risk of the pituitary becoming less responsive

Less commonly, injection site reactions can be larger and more widespread