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Indeed, disruptions to epithelial barrier functions and a leaky gut are implicated in both intestinal and extraintestinal pathologies, including allergic and autoimmune conditions, inflammatory bowel diseases, irritable bowel syndrome and cancer 5

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There are no known cases of overdose when taking dietary supplements or high-dose vitamin B12 medications

Furthermore, a palmitoylated form of the compound, Pal-GHK, may also decrease the generation of reactive oxygen species and inflammatory cytokines, while potentially enhancing the activity of antioxidant enzymes

Therefore, although the researchers were able to demonstrate that intranasal glutathione supplementation could have a positive impact on patient symptoms, they failed to demonstrate these effects were distinct from a placebo effect