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PEG-MGF (Pegylated Mechano Growth Factor) is a synthetic peptide derived from the unique C-terminal E-domain of IGF-1Ec the mechanosensitive splice variant of the insulin-like growth factor 1 gene expressed locally in skeletal muscle and other tissues in response to mechanical stretch, injury, exercise, and hypoxia

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Johnson JB, Summer W, Cutler RG, et al

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4.1 MQC dysfunction may contribute to chondrocyte hypertrophy Chondrocyte hypertrophy, a typical phenotypic aberration in OA, is characterized by the upregulation of hypertrophic markers such as Runx2 and type COL10A1-a cellular state that has been closely correlated with MQC dysfunction in both in vitro and in vivo models (55, 56)

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