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This implies that the activated receptor is primed to activate multiple rounds of G protein coupling following dissociation of the initial interacting protein, and this is proposed to contribute to the sustained cAMP signalling following activation of class B1 GPCRs

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In addition to acting on neuronal cells, GLP-1R agonists also exert effects on microglia and astrocytes through cAMP/PKA signaling pathway

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Copper-induced oxidative stress also promotes inflammation through ROS production, resulting in lipid, protein and DNA damage (70)