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While originally developed to treat Type 2 diabetes, these medications are now frequently prescribed for chronic weight management in the UK, provided the patient meets specific criteria regarding Body Mass Index (BMI) and weight-related health conditions

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Dig Dis Sci 58 , 26462652 (2013)

The most common are gastrointestinal: Nausea the most frequently reported side effect, especially during dose increases Vomiting less common than nausea, but can occur during titration Diarrhea typically mild and temporary Constipation some patients experience this instead of or in addition to diarrhea Decreased appetite this is both a therapeutic effect and something patients notice as a side effect These side effects are generally most noticeable in the first few weeks of treatment or after a dose increase, and tend to improve as the body adjusts

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This acylation facilitates high-affinity binding to plasma albumin, which significantly extends its half-life and stability in research substrates compared to native incretins