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Both GLP-1 and its agonists (GLP-1RAs) have been identified for suppressing appetite, slowing gastric emptying time, and inducing fullness and satiety, thereby reducing caloric intake under ad libitum feeding conditions (139141)

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The transcriptional program induced by cystine deprivation is similar to that of leucine starvation 14 , suggesting that the transcriptional program is a common adaptation of amino acid starvation to activate amino acid metabolism and stress resistance

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