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Semaglutides weight loss effects have also driven up demand for the drug, leading to high costs, medication shortages and the use of potentially dangerous compounded versions for some

A multicenter, randomized, open-label, phase 3b trial, SURMOUNT-5 was launched to compare the efficacy and safety of tirzepatide compared with semaglutide in adults with obesity or overweight without diabetes and at least 1 of the following comorbidities: hypertension, dyslipidemia, obstructive sleep apnea, or cardiovascular disease

Shin JS, Huh YS

doi: 10.1016/j.jaci.2021.06.012 198 PulendranBS ArunachalamPOHaganDT

Zhang D, Li AM, Hu G, Huang M, Yang F, Zhang L, et al