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The drug is broken down into smaller amino acid components through proteolytic degradation, with the resulting metabolites eliminated via urine and faeces
As in the LEAN study, the primary outcome is histologic resolution of NASH without worsening of fibrosis after 72 weeks of treatment, while secondary outcomes include improvement in liver fibrosis (1 stage) with no worsening of NASH, NAFLD activity score, as well as multiple serum markers of fibrosis
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The medications interaction profile also necessitates careful consideration, particularly with substances that can lower the seizure threshold or interact with its metabolic pathway
While further long-term studies are warranted to validate these results, integrating GLP- as primary therapeutic agents may represent a paradigm shift in preventing the cognitive complications of diabetes. A number of other researchers have come forward to comment on the study
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