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The contraindications are due to health concerns
The model accounted for changes in weight and cardiovascular risk factors after 2 years of treatment, drug discontinuation due to adverse events, and long-term cardiovascular disease events, such as coronary heart disease and stroke
Consequently, carbidopa administration has been associated with PD elevated death rate, progressive neurodegenerative course, and l-DOPA tachyphylaxis (70)
Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.
Glia 59 , 119131 (2011)
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