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Headache 60(4):655664 Won L, Kraig RP (2020) Insulin-like growth factor-1 inhibits spreading depression-induced trigeminal calcitonin gene related peptide, oxidative stress & neuronal activation in rat

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The SELECT trial extended that finding to non-diabetic overweight and obese populations with a 20% MACE reduction (HR 0.80, 95% CI 0.72 to 0.90) across 17,604 participants

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