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The severe deficiency of this enzyme results in a reduction of the NADPH generation, which results in a decrease in the production of hydrogen peroxide (H 2 O 2 ) and therefore the neutrophil microbicide activity is affected and likewise its inflammatory response 16
Our combination therapy of (-)-Vestitol and Salviolone, identified via network medicine, targets multiple AD-related pathways, including Neuroactive ligand-receptor interaction and Calcium signaling pathway, potentially offering a more comprehensive, disease-modifying approach
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