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Gastrointestinal side effects (flatulence, diarrhoea) may limit tolerability

Meanwhile, the nanoformulation-enhanced membrane interaction could influence ECM remodeling more directly, optimizing the MMP/TIMP balance, as shown by Taherkhani et al

Mammalian and human studies showed that dyslipidaemia is accompanied frequently by inflammation 34

A randomised cross-over clinical trial has shown that, compared to the standard administration route, direct delivery within the urethral meatus can increase efficacy and confidence among patients, without increasing adverse effects [446]

But giving folate does lower folate

doi: 10.1136/annrheumdis-2020-217251