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Moreover, erythrocytes express calpain-1 [110], a Ca 2+ -dependent protease that may contribute to the breakdown of the cytoskeleton during eryptosis

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C9orf72 and Rab7l1 regulate vesicle trafficking in amyotrophic lateral sclerosis and frontotemporal dementia

That is not always obvious at the time, which is why dose and schedule should be set against a confirmed clinical picture rather than guesswork