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A larger randomized, placebo-controlled intervention trial (the SELECT study) in more than 35,000 middle-aged and selenium-replete men, randomized to receive selenium (in the form of selenomethionine, 200 g/day) and/or vitamin E supplementation, was halted because of concerns regarding an increased risk of type 2 diabetes mellitus with selenium and increased risk of prostate cancer with vitamin E (84, 85)

Wait until barrier is robust and inflammatiion is down

(PubMed) Bermingham EN, Hesketh JE, Sinclair BR, Koolaard JP, Roy NC

One hundred type 2 diabetes mellitus patients on metformin 4 months with vitamin B12 deficiency were enrolled in this study and randomized equally into two groups

PMID 36833260

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